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Ros1 is highly homologous with alk, and can also regulate normal physiological activities of cells I strongly advise against intentionally pursuing mutations for causing lung cancer, as this would be harmful and unethical The overexpression of both is closely related to the development and metastasis of tumors

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Although their frequency is relatively low, their detection is important for patient care and guides therapeutic decisions Similarly to alk nsclc, patients with ros1+ nsclc tend to have minimal smoking history and be of the female sex. The accepted methods used for th …

Introduction anaplastic lymphoma kinase (alk) is a tyrosine kinase that can be aberrantly expressed in several tumor types

The most common alk rearrangement in nsclc juxtaposes the 5' end of the echinoderm microtubule.